12.3 Pharmacokinetics . Cyclophosphamide works by damaging the DNA of cancer cells. Cyclophosphamide-induced sterility may be irreversible in some patients. cyclophosphamide” scheme in which administration of allogeneic spleen cells followed by cyclophosphamide administration 2 days thereafter induced tolerance to allo-grafts in different mouse models. Springer, Boston, MA.
It is a treatment for a number of different types of cancer. Blood Rev 1992; 6:163. Pregnancy. Drug Class- Cytotoxic/Immunosuppressive Mechanism of Action Drugs of this class suppress the natural immune system including B and T lymphocyte activity and function. 15 REFERENCES 16 …
Effects of cyclophosphamide on B- and T-lymphocytes in rheumatoid arthritis. cyclophosphamide listen (SY-kloh-FOS-fuh-mide) A drug used to treat many types of cancer. Mechanisms of Action Cyclophosphamide, a nitrogen mustard, is an alkylating agent from the oxazophosphorine group (Figure 1). 13 NONCLINICAL TOXICOLOGY . It is also being studied in the treatment of cancer. Yes, it is. It is best to read this information with our general information about chemotherapy and the type of cancer you have.. Cyclophosphamide is an alkylating drug indicated for treatment of: ... 12.1 Mechanism of Action . Abstract. Development of sterility appears to depend on the dose of cyclophosphamide, duration of therapy, and the state of gonadal function at the time of treatment. Cyclophosphamide damages the cell’s DNA and may kill cancer cells. How cyclophosphamide works. A course of cyclophosphamide administered to guinea pigs after immunization with mycobacteria led to a transient inhibition of cutaneous hypersensitivity to tuberculin protein. 12.2 Pharmacodynamics . Advances in Experimental Medicine and Biology, vol 518. The mechanism of action is thought to involve cross-linking of tumor cell DNA. The effects of cyclophosphamide an antinuclear antibody levels, immune complex deposition in renal glomeruli, glomerular cell proliferation and glomerulosclerosis in the (NZB x NZW)F1 hybrid mouse have been investigated in order to better understand the mechanism of action of this drug on nephritis. Exposure to cyclophosphamide during pregnancy may cause fetal malformations, miscarriage, fetal growth retardation, and toxic effects in the newborn. It is one of the most potent immunosuppressive drugs available. Several studies have examined the mechanism of action of cyclophosphamide. Vb6-bearing T cells directed to minor lymphocyte stimu-
Cyclophosphamide. Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells.
Cyclophosphamide for injection may be administered as an IV infusion when reconstituted with 0.9% Sodium Chloride injection or Sterile Water for injection and further diluted in 5% Dextrose Injection USP, 5% Dextrose and 0.9% Sodium Chloride injection USP, or 0.45% sterile sodium chloride to a minimum concentration of 2 mg/mL. Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment. Although not FDA approved, other kidney diseases caused by a disrupted immune system have been treated …
Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies.
Cyclophosphamide Mechanism of Action. Cyclophosphamide is used to treat breast cancer, lung cancer, leukaemia, lymphoma, and myeloma.It may sometimes be used to treat other cancers. Mechanism of action. This metabolite is only formed in cells that have low levels of ALDH. Carcinogenesis, Mutagenesis, Impairment of Fertility . Diseases Treated with this Medication This medication is primarily used to treat cancers and nephrotic syndrome.
Cyclophosphamide is well absorbed after oral administration with a bioavailability greater than 75%. Mechanism of action. Robaire B., Hales B.F. (2003) Mechanisms of Action of Cyclophosphamide as a Male-Mediated Developmental Toxicant. Cyclophosphamide (pronounced sigh-clo-fos-fah-mide) is a type of chemotherapy. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively).
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